Spontaneous Mutation: Comparative Rates of Spontaneous Mutation
نویسندگان
چکیده
منابع مشابه
Rates of spontaneous mutation.
Rates of spontaneous mutation per genome as measured in the laboratory are remarkably similar within broad groups of organisms but differ strikingly among groups. Mutation rates in RNA viruses, whose genomes contain ca. 10(4) bases, are roughly 1 per genome per replication for lytic viruses and roughly 0.1 per genome per replication for retroviruses and a retrotransposon. Mutation rates in micr...
متن کاملRates of spontaneous mutation among RNA viruses.
Simple methods are presented to estimate rates of spontaneous mutation from mutant frequencies and population parameters in RNA viruses. Published mutant frequencies yield a wide range of mutation rates per genome per replication, mainly because mutational targets have usually been small and, thus, poor samples of the mutability of the average base. Nevertheless, there is a clear central tenden...
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Mildly deleterious mutation has been invoked as a leading explanation for a diverse array of observations in evolutionary genetics and molecular evolution and is thought to be a significant risk of extinction for small populations. However, much of the empirical evidence for the deleterious-mutation process derives from studies of Drosophila melanogaster, some of which have been called into que...
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To estimate the efficacy of mechanisms which may prevent or repair thermal damage to DNA in thermophilic archaea, a quantitative assay of forward mutation at extremely high temperature was developed for Sulfolobus acidocaldarius, based on the selection of pyrimidine-requiring mutants resistant to 5-fluoro-orotic acid. Maximum-likelihood analysis of spontaneous mutant distributions in wild-type ...
متن کاملSpontaneous mutations and mutation rates in the house mouse.
HE frequency of occurrence of spontaneous mutations has been under investigation in the extensive mouse breeding colonies of the Jackson Laboratory since the autumn of 1963. The primary goal of this study is to estimate the spontaneous mutation rates, both forward and reverse, at each of five specific coat-color loci (non-agouti, a, brown, b, albino, c, dilute, d, and leaden, In). A secondary g...
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ژورنال
عنوان ژورنال: Nature
سال: 1969
ISSN: 0028-0836,1476-4687
DOI: 10.1038/2211132a0